apalutamide will decrease the level or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with prescription drugs which are CYP2C19 substrates may end up in reduced publicity to those drugs.
diazepam raises levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Lomitapide dose shouldn't exceed thirty mg/working day.
deferasirox will decrease the extent or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Restrict dosage and period if concomitantly used; observe closely for respiratory depression and sedation
Diazepam could interfere with metabolism of substrates for CYP2C19 and CYP3A4 leading to a possible drug-drug interaction
Reserve concomitant prescribing of those medicine for use in patients for whom alternate remedy possibilities are insufficient
rifapentine will lessen the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
diazepam will increase the degree or effect of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may well cause larger midazolam systemic exposure, which may lengthen sedation.
Observe Closely (1)triclabendazole will improve the amount or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism.
Because of isolated studies of neutropenia and jaundice, periodic blood counts and liver perform assessments are sensible throughout extensive-phrase therapy
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2nd dose: When expected, may be administered after not less than 4 hr after First dose; if the second dose is administered, make use of a new blister pack of diazepam intranasal
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